Note: To view the object in its own window, select it in the Object Browser and double-click it or press ENTER. Or right-click menu for a worksheet: Send To > NONMEM > NONMEM Shell. Or Main menu: Insert > NONMEM > NONMEM Shell. Right-click menu for a Workflow object: New > NONMEM > NONMEM Shell. Use one of the following to add a NONMEM object to a Workflow: Note: Phoenix program plugins, such as the NONMEM object, assume that the corresponding third party software is installed and running properly. Enhanced annealing feature for SAEM to facilitate estimation of fixed effect parameters (THETAs) that do not have associated inter-subject variance (ETA’s).The NONMEM object runs NONMEM models by using NONMEM control files and datasets.Variance matrix parameters in covariance, correlation, or Cholesky format.Variance matrix parameters output in covariance and correlation format.Symbolic reference to thetas, etas, and epsilons.Multiple mixed effects levels, with random effects across groups of individuals such as clinical site.Capable of using the first-order conditional estimation method.Dynamic memory allocation according to problem size.Parallel computing of a single problem over multiple cores or computers.Markov-Chain Monte Carlo Bayesian Analysis (BAYES).Stochastic Approximation Expectation-Maximization (SAEM).Importance Sampling Expectation-Maximization (IMP).First Order Conditional Estimation (FOCE).The following population analysis methods must be available:.The Contractor shall provide a brand name or an equal-to product that meets the following software license salient characteristics. The salient characteristics for the NONMEM Software License, brand name or equal, are listed below. “Objective: The objective of this requirement is to renew NONMEM/PDx-PoP software license subscription or acquire an equivalent software that can meet the Government’s needs.”
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